Blood (1/3)-b-D-Glucan as a Diagnostic Test for HIV-Related Pneumocystis jirovecii Pneumonia
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چکیده
Paul E. Sax,1 Lauren Komarow,2 Malcolm A. Finkelman,3 Philip M. Grant,4 Janet Andersen,2 Eileen Scully,1 William G. Powderly,5 and Andrew R. Zolopa4 for the AIDS Clinical Trials Group Study A5164 Team 1Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and 2Harvard School of Public Health, Boston, 3Associates of Cape Cod, East Falmouth, Massachusetts; 4Division of Infectious Diseases and Department of Medicine, Stanford University School of Medicine, Stanford, California; and 5School of Medicine, University College Dublin, Ireland
منابع مشابه
Blood (1->3)-beta-D-glucan as a diagnostic test for HIV-related Pneumocystis jirovecii pneumonia.
UNLABELLED (See the editorial commentary by Morris and Masur, on pages 203-204.) BACKGROUND Improved noninvasive diagnostic tests for Pneumocystis jirovecii pneumonia (PCP) are needed. We evaluated the test characteristics of plasma (1 → 3)-β-D-glucan (β-glucan) for HIV-related PCP among a large group of patients presenting with diverse opportunistic infections (OIs). METHODS The study popu...
متن کاملPneumocystis pneumonia associated with human immunodeficiency virus infection without elevated (1 → 3)-β-D glucan: A case report
Pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii is one of the most common opportunistic infections in immunosuppressed patients, particularly in patients with acquired immunodeficiency syndrome (AIDS). (1 → 3)-β-D-glucan is a component of the cell wall of P. jirovecii and other fungi such as Candida sp., Aspergillus sp. and Histoplasma sp. The measurement of serum (1 → 3)-β-D-gluc...
متن کاملSerum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study
BACKGROUND In patients with chronic respiratory disease, Pneumocystis jirovecii (P. jirovecii) colonization is observed, and may influence disease progression and systemic inflammation. Pneumocystis pneumonia causes interstitial changes, so making a diagnosis of PCP in patients who have interstitial pneumonia (IP) with P. jirovecii colonization is sometimes difficult based on radiography. MET...
متن کاملDiagnostic performance of the (1–3)-β-D-glucan assay in patients with Pneumocystis jirovecii compared with those with candidiasis, aspergillosis, mucormycosis, and tuberculosis, and healthy volunteers
BACKGROUND Diagnosis of pneumocystis pneumonia (PCP) relies on microscopic visualization of P. jirovecii, or detection of Pneumocystis DNA in respiratory specimens, which involves invasive procedures such as bronchoalveolar lavage. The (1-3)-β-D-glucan (BG) assay has been proposed as a less invasive and less expensive diagnostic test to rule out PCP. We therefore compared blood levels of BG in ...
متن کاملSerum (1-3)-beta-D-glucan as a tool for diagnosis of Pneumocystis jirovecii pneumonia in patients with human immunodeficiency virus infection or hematological malignancy.
(1-3)-Beta-D-Glucan (BG) reactivity was tested in serum samples from 28 patients with human immunodeficiency virus infection or a hematological malignancy and Pneumocystis jirovecii pneumonia (PCP) and 28 control patients. The sensitivity and specificity of BG detection with the Fungitell assay for PCP were 100 and 96.4%, respectively, using a cutoff value of 100 pg/ml. Serum BG testing looks p...
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تاریخ انتشار 2011